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The Food and Drug Administration, FDA, has approved the drug Vivitrol for the treatment of opioid dependence based on a news release by them on 10-12-2010.

Using two separate drugs to shed pounds can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it one should err to the side of caution and let the FDA do its job and demand some investigation be done so the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say everything to keep people on their medications.

Researchers found out that participants taking this drug for any year, dropped a few pounds within one month and have kept the extra weight off throughout the 56 weeks with the study. Contrave can be a combination of the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which are made up of multiple active ingredient, which may make them more effective and safer.

Combo-pilling will be the newest fad or in addition to this the newest in the future under scrutiny and therefore it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is now popular could be the fact that by right now there are not any long term prescription diet pills that have been authorized by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug can also raise hypertension and heartrate, and shouldn't be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure levels, along with by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients having a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.


From a psychiatric point of view, evidence points too the ordinary neural mechanism for goal-directed behavior has become hijacked through the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus along with the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).